name	1.1
namespace	http://purl.org/obo/owlapi/tf_classification_human#
parent	 1 
child	 1.1.0 
child	 1.1.8 
child	 1.1.7 
child	 1.1.6 
child	 1.1.5 
child	 1.1.4 
child	 1.1.3 
child	 1.1.2 
child	 1.1.1 
def []	"TRANSFAC class description C0008: A DNA-binding basic region is followed by a leucine zipper. The leucine zipper consists of repeated leucine residues at every seventh position and mediates protein dimerization as a prerequisite for DNA-binding. The leucines are directed towards one side of an alpha-helix. The leucine side chains of two polypeptides are thought to interdigitate upon dimerization (knobs-into-holes model). The leucine zipper dictates dimerization specificity. Upon DNA-binding of the dimer, the basic regions adopt alpha-helical conformation as well. Possibly, a sharp angulation point separates two alpha-helices of the subregions A and B leading to the scissors grip model for the bZIP-DNA complex. The DNA is contacted through the major groove over a whole turn." []
label []	Basic leucine zipper factors (bZIP)
xref []	CLASSLINK:http\://www.edgar-wingender.de/class 1.1.html
subset []	Class