http://purl.org/obo/owlapi/tf_classification_human#4.1

Properties

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[] Class
def
[] "TRANSFAC® class description C0015: Proteins of this class comprise a region of homology with the chromosomal non-histone HMG proteins such as HMG1. This region comprises the DNA-binding domain which in some instances such as HMG1 mediates sequence-unspecific, in other cases such LEF-1 sequence-specific binding to DNA. This domain exhibits a typical L-shaped conformation made up of 3 alpha-helices and an extended N-terminal extension of the first helix. The latter together with helix 1, which contains a kink, form the long arm of the L, whereas helices 1 and 2 form the short arm. Binding to the minor groove induces a sharp bending of the DNA by more than 90 degree, away from the bound protein. The overall topology of the DNA-protein complexes resembles somewhat that of the TBP-TATA box complex." []
xref
[] CLASSLINK:http\://www.edgar-wingender.de/class 4.1.html
label
[] High-mobility group (HMG) domain factors

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