http://purl.org/obo/owlapi/tf_classification_human#6.2

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[] CLASSLINK:http\://www.edgar-wingender.de/class 6.2.html
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[] Class
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[] STAT domain factors
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[] "Class description: STAT proteins bind to DNA as dimers. The DNA-contacting interface is organized by an eight-stranded beta-barrel, N-terminally preceded by a four-helix bundle and C-terminally followed by a mostly alpha-helical connector region. The residues that bind to the major groove of the DNA are mostly exposed by loops connecting the beta-strands of the beta-barrel and the one linking the beta-barrel and the first helix of the 'connector' region. The STAT dimer nearly completely embraces the DNA double helix, compared with a 'pair of pliers' (PMID 9671298), with the DNA-binding interface as jaws and the four-helix bundles as handles. Bound by STAT, the DNA undergoes a moderate bending of about 40 degrees. (PMID 9671298)" []

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