http://purl.org/obo/owlapi/tf_classification__mouse#1.1

Properties

subset
[] Class
def
[] "TRANSFAC class description C0008: A DNA-binding basic region is followed by a leucine zipper. The leucine zipper consists of repeated leucine residues at every seventh position and mediates protein dimerization as a prerequisite for DNA-binding. The leucines are directed towards one side of an alpha-helix. The leucine side chains of two polypeptides are thought to interdigitate upon dimerization (knobs-into-holes model). The leucine zipper dictates dimerization specificity. Upon DNA-binding of the dimer, the basic regions adopt alpha-helical conformation as well. Possibly, a sharp angulation point separates two alpha-helices of the subregions A and B leading to the scissors grip model for the bZIP-DNA complex. The DNA is contacted through the major groove over a whole turn." []
xref
[] CLASSLINK:http\://www.edgar-wingender.de/class 1.1.html
label
[] Basic leucine zipper factors (bZIP)

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