http://purl.org/obo/owlapi/tf_classification__mouse#2.6

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[] Class
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[] CLASSLINK:http\://www.edgar-wingender.de/class 2.6.html
def
[] "Class description: CXXC zinc fingers contain two zinc ion binding 4-cysteine patterns, each of them comprising a CGxCxxC motif and a distantly located cysteine. One of these patterns (with lower-case Cs) is embedded within the other (with upper-case Cs): C-x(2)-C-x(2)-C-x(5,6)-c-x(2)-c-x(2)-c-x(9,15)-c-x(4)-C. The second and third cysteine of each motif lie within a short alpha-helix. The overall finger structure also forms a two-stranded antiparallel beta-sheet, the two beta-strands being located immediately N- and C-terminally adjacent to the CXXC zinc finger pattern. The CXXC zinc finger binds to DNA at CpG-containing sequences, most of the contacts are exerted by residues of an extended loop in the x(9,15) region of the above signature. (PMID 16990798)" []
label
[] CXXC zinc finger factors

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