name	4.1
namespace	http://purl.org/obo/owlapi/tf_classification__mouse#
parent	 4 
child	 4.1.7 
child	 4.1.6 
child	 4.1.5 
child	 4.1.4 
child	 4.1.3 
child	 4.1.2 
child	 4.1.1 
subset []	Class
def []	"TRANSFAC<sup>&reg;</sup> class description C0015: Proteins of this class comprise a region of homology with the chromosomal non-histone HMG proteins such as HMG1. This region comprises the DNA-binding domain which in some instances such as HMG1 mediates sequence-unspecific, in other cases such LEF-1 sequence-specific binding to DNA. This domain exhibits a typical L-shaped conformation made up of 3 alpha-helices and an extended N-terminal extension of the first helix. The latter together with helix 1, which contains a kink, form the long arm of the L, whereas helices 1 and 2 form the short arm. Binding to the minor groove induces a sharp bending of the DNA by more than 90 degree, away from the bound protein. The overall topology of the DNA-protein complexes resembles somewhat that of the TBP-TATA box complex." []
xref []	CLASSLINK:http\://www.edgar-wingender.de/class 4.1.html
label []	High-mobility group (HMG) domain factors