name 6.1 namespace http://purl.org/obo/owlapi/tf_classification__mouse# parent 6 child 6.1.4 child 6.1.3 child 6.1.2 child 6.1.1 child 6.1.5 subset [] Class label [] Rel homology region (RHR) factors xref [] CLASSLINK:http\://www.edgar-wingender.de/class 6.1.html def [] "TRANSFAC® class description C0020: The structure of the Rel-type DBD exhibits a bipartite subdomain structure, each subdomain comprising a beta-barrel with five loops that form an extensive contact surface to the major groove of the DNA. Particularly, the first loop of the N-terminal subdomain (the highly conserved recognition loop) performs contacts with the recognition element on the DNA, but other loops are involved. The fact that the main DNA-contacts are made through loops has been suggested to provide a high degree of flexibility in binding to a range of different target sequences. Augmenting interactions are achieved by two alpha-helices within the N-terminal part that form strong minor groove contacts to the A/T-rich center of the B-element. In p65, the sequence between both alpha-helices is much shorter and even helix 2 is truncated. The second, C-terminal domain is necessary mainly for protein dimerization." []